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In Trial 7, cholecystitis was reported in 1.1% treated with semaglutide tablets 14 mg and in 0.7% of placebo-treated patients

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Furthermore, standard extrapolation of the fomepizole dose that prevents JNK activation in mice to humans would suggest a human equivalent dose of about 4 mg/kg, more than 3 times lower than the standard 15 mg/kg loading dose used clinically